Reaction Mechanism of Bovine Heart Cytochrome Oxidase.
نویسندگان
چکیده
منابع مشابه
COMMEMORATIVE LECTURE Reaction Mechanism of Bovine Heart Cytochrome Oxidase
As I mentioned at the awards ceremony a little while ago, the work for which I have received the Keio Med ical Award is not something that I have been able to accomplish alone; it has involved the cooperation of many scientists. Dr. Tsukihara is Professor of the Insti tute for Protein Research, Osaka University, and spe cializes in X-ray crystallography. Dr. Kitagawa and Dr. Ogura, who is here ...
متن کاملReaction mechanism and phospholipid structures of bovine heart cytochrome c oxidase.
Bovine heart cytochrome c oxidase is a large multi-component membrane protein containing several phospholipids. X-ray structures of this enzyme at high resolution, determined recently, show a trigonal planar structure of CuB site in the O2 reduction site, which could contribute critically to the four-electron reduction of O2 bound at haem a3, and a hydrogen bond network, through which the proto...
متن کاملX-ray structure and reaction mechanism of bovine heart cytochrome c oxidase.
X-ray structure of bovine heart cytochrome c oxidase in the fully oxidized state shows a peroxide bridging between Fe2+ and Cu2+ in the O2 reduction site. The bond distances for Fe-O and Cu-O are 2.52 and 2.16 A, respectively. The structure is consistent with antiferromagnetic coupling between the two metals, which has long been known and to recent redox titration results [J. Biol. Chem. 274 (1...
متن کاملThe reaction of cytochrome oxidase with cyanide.
The ability of cyanide to inhibit the oxygen consumption of biological systems has long been known (cf. (4, 13)). Warburg (12, 13) appears to be the first to suggest that this action of cyanide was due t,o its combination with the ferric form of the enzyme, called by hi the Atmungaferment and later called cytochrome oxidase by Keilin and Hartree (5). In this paper we make use of this reaction o...
متن کاملThe Reaction of Cytochrome Oxidase with Cytochrome c*
In recent work on the reaction between oxygen and reduced cytochrome oxidase made by the method of Yonetani (1)) Gibson and Greenwood (2) found that the reaction is complex and that at least two spectroscopically distinguishable reactions must take place. The kinetic changes were interpreted in terms of a scheme proposed by Keilin and Hartree (3), according to which cytochrome oxidase preparati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 2000
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.49.99